We are in the grip of an allergy epidemic. 50 years ago one in 30 were affected, but in Britain today it is closer to one in three. Why this should be is one of modern medicine's greatest puzzles. In search of answers, Horizon travels round the globe, from the remotest inhabited island to the polluted centres of California and the UK. We meet sufferers and the scientists who have dedicated their lives trying to answer the mystery of why we are becoming allergic to our world.

Austrian director Michael Glawogger travels to five countries to focus on some of the worst jobs imaginable: Ukrainian miners crawl into tiny cracks in old coal pits to scratch out a few bags of winter fuel; Indonesian workers trudge long distances carrying baskets with hundreds of pounds of sulfur chunks extracted from a steaming mountain; Pakistanis risk explosions and burial under tons of scrap iron as they dismantle huge carrier ships. The visuals are everything here. Despite the hardships depicted, many sequences have a dreamlike beauty. In addition, the director has a bone-dry sense of irony; during the Ukraine scenes, he frequently cuts away to a statue of Stakhanov, the "hero" lauded by the Soviets for his superhuman work habits. He also shows us an old German smelting works that's been converted into a theme park.