40,000 years ago the steppes of Eurasia were home to our closest human relative, the Neanderthals. Recent genetic and archaeological discoveries have proven that they were not the dim-witted cave dwellers we long thought they were. In fact, they were cultured, technologically savvy and more like us than we ever imagined! So why did they disappear? We accompany scientists on an exciting search for an answer to this question and come to a startling conclusion... A climate change due to a cataclysmic event.

The series takes place after the extinction of the dinosaurs 65 million years ago and recreates animals of the Cenozoic with computer-generated imagery and animatronics. The first episode starts 49 million years ago, when Earth has fully recovered from the dinosaur extinction and is covered in a mysterious forest. This is a time that the world has almost forgotten - Germany was a hot sweaty jungle, birds ruled the earth and preyed on miniature horses and whales walked on land.

Take a look at the issues that will change the way we live our lives in the future. Hannah Fry delves into the data we have today to provide an evidence-based vision of tomorrow. With the help of science experts Hannah tries to discover whether we could ever live forever or if there will ever be a cure for cancer. She finds out how research into the human brain may one day help with mental health, and if it is possible to ever ditch fossil fuels. Hannah and her guests also discover the future of transport - and when, if ever, we really will see flying cars. She discovers whether a robot will take your job or if, as some believe, we will all one day actually become cyborgs. The programme predicts what the weather will be like and discovers if we are on the verge of another mass extinction. Hannah's tenth prediction is something she - and Horizon - are confident will definitely happen, and that is to expect the unexpected!

Long ago, two species of human beings coexisted on Earth until competition drove one of them to extinction. This program, set in the southwest of France 35,000 years ago, reconstructs the life in the Neanderthal world at the time Cro-Magnons first entered the scene. All aspects of Neanderthal clan life are examined, including tool- and weapon-making, hunting and gathering, health and healing, childbirth, rituals, and making fire. Footage of skeletal remains and the scholarly research of eminent paleontologist Chris Stringer and Oxford University's Paul Pettitt support the documentary.

The first episode looks at how birds first took to the skies in the wake of the insects. It begins in Mexico, where Sir Attenborough observes bats being outmanoeuvred by a red-tailed hawk. Pterosaurs were the birds' forerunners, some 150 million years after dragonflies developed the means of flight, but eventually went extinct together with the dinosaurs. Birds had by then already evolved from early forms like archaeopteryx, the first creature to possess feathers. Its ancestry can be traced through reptiles, and some current species, such as the flying lizard, possibly show paths this evolution may have taken." One of the biggest birds to have ever existed was the terror bird, which proliferated after dinosaurs vanished and stood up to 2.5 metres tall. By comparison, the ostrich, while not closely related, is the largest and heaviest living bird. It was probably the evasion of predators that drove most birds into the air, so their flightless cousins evolved because they had few enemies. Accordingly, such species are more likely to be found on islands, and Sir Attenborough visits New Zealand to observe its great variety, most especially the kiwi. Also depicted is the moa, another huge creature that is now gone. The takahē is extremely rare, and high in the mountains of New Zealand, Sir Attenborough discovers one from a population of only 40 pairs. Finally, another example on the brink of extinction is the kakapo, which at one point numbered only 61 individuals. A male is heard calling — an immensely amplified deep note that can be heard at great distances from its nest.

Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).