Some of the world's leading physicists believe they have found startling new evidence showing the existence of universes other than our own. One possibility is that the universe is so vast that an exact replica of our solar system, our planet and ourselves exists many times over. These Doppelganger Universes exist within our own Universe; in what scientist now call "The Multiverse." If proof is found it will change our lives, our minds, our planet, our science and our universe.

The story begins with Tyson sitting at a campfire, and telling how the wolf changed through artificial selection, and selective breeding into the dog breeds around today. He then enters the Ship of Imagination, and explains natural selection with the process that helped to create the polar bears. Along the way he talks about DNA, genes and mutation. Next he goes to a forest and describes the Tree of life, this leads him to discussing the evolution of the eye. He then discusses extinction, by going to a monument called the Halls of Extinction, dedicated to the broken branches of the tree of life. Explaining the five great Extinction events. He then tells how some life has survived, and then focuses on the tardigrade. From there he talks about what other kinds of life might have been created on other worlds. He then goes to Saturn's moon Titan. From there he speculates about life and how it first began. He then returns to Earth and tells about abiogenesis and how life changed and evolved. The show ends with an animated sequence from the original series of life's evolution from one cell to humans.

Tyson begins the episode by explaining the nature of the speed of light and how much of what is seen of the observable universe is from light emanated from billions of years in the past. Tyson further explains how modern astronomy has used such analyzes via deep time to identify the Big Bang event and the age of the universe. Tyson proceeds to describe how the work of Isaac Newton, William Herschel, and James Clerk Maxwell contributed to understanding the nature of electromagnetic waves and gravitational force, and how this work led towards Albert Einstein's Theory of Relativity, that the speed of light is a fundamental constant of the universe and gravity can be seen as distortion of the fabric of space-time. Tyson describes the concept of dark stars as postulated by John Michell which are not visible but detectable by tracking other stars trapped within their gravity wells, an idea Herschel used to discover binary stars. Tyson then describes the nature of black holes, their enormous gravitational forces that can even capture light, and their discovery via X-ray sources such as Cygnus X-1. Tyson uses the Ship of Imagination to provide a postulate of the warping of spacetime and time dilation as one enters the event horizon of the black hole, and the possibility that these may lead to other points within our universe or others, or even time travel. Tyson ends on noting that Herschel's son, John would be inspired by his father to continue to document the known stars as well as contributions towards photography that play on the same nature of deep time used by astronomers.

Carl Sagan teaches students in a classroom in his childhood home in Brooklyn, New York, which leads into a history of the different mythologies about stars and the gradual revelation of their true nature. In ancient Greece, some philosophers (Aristarchus of Samos, Thales of Miletus, Anaximander, Theodorus of Samos, Empedocles, Democritus) freely pursue scientific knowledge, while others (Plato, Aristotle, and the Pythagoreans) advocate slavery and epistemic secrecy.

This episode explores the wave theory of light as studied by mankind, noting that light has played an important role in scientific progress, with such early experiments from over 2000 years ago involving the camera obscura by the Chinese philosopher Mozi. Tyson describes the work of the 11th century Arabic scientist Ibn al-Haytham, considered to be one of the first to postulate on the nature of light and optics leading to the concept of the telescope, as well as one of the first researchers to use the scientific method. Tyson proceeds to discuss the nature of light as discovered by mankind. Work by Isaac Newton using diffraction through prisms demonstrated that light was composed of the visible spectrum, while findings of William Herschel in the 19th century showed that light also consisted of infrared rays. Joseph von Fraunhofer would later come to discover that by magnifying the spectrum of visible light, gaps in the spectrum would be observed. These Fraunhofer lines would later be determined to be caused by the absorption of light by electrons in moving between atomic orbitals when it passed through atoms, with each atom having a characteristic signature due to the quantum nature of these orbitals. This since has led to the core of astronomical spectroscopy, allowing astronomers to make observations about the composition of stars, planets, and other stellar features through the spectral lines, as well as observing the motion and expansion of the universe, and the existence of dark matter.

This episode is centered around how science, in particular the work of Clair Patterson (voiced in animated sequences by Richard Gere[33]) in the middle of the 20th century, has been able to determine the age of the Earth. Tyson first describes how the Earth was formed from the coalescence of matter some millions of years after the formation of the Sun, and while scientists can examine the formations in rock stratum to date some geological events, these can only trace back millions of years. Instead, scientists have used the debris from meteor impacts, such as the Meteor Crater in Arizona, knowing that the material from such meteors coming from the asteroid belt would have been made at the same time as the Earth. Patterson also examined the levels of lead in the common environment and in deeper parts of the oceans and Antarctic ice, showing that lead had only been brought to the surface in recent times. He would discover that the higher levels of lead were from the use of tetraethyllead in leaded gasoline resulting in government-mandated restrictions on the use of lead.