The episode begins with Tyson describing how pattern recognition manifested in early civilization as using astronomy and astrology to predict the passing of the seasons, including how the passage of a comet was often taken as an omen. Tyson continues to explain that the origin of comets only became known in the 20th century due to the work of Jan Oort and his hypothesis of the Oort cloud. Tyson then continues to relate the collaboration between Edmond Halley and Isaac Newton in the last part of the 17th century in Cambridge. The collaboration would result in the publication of Philosophiæ Naturalis Principia Mathematica, the first major work to describe the laws of physics in mathematical terms, despite objections and claims of plagiarism from Robert Hooke and financial difficulties of the Royal Society of London. Tyson explains how this work challenged the prevailing notion that God had planned out the heavens, but would end up influencing many factors of modern life, including space flight. Tyson further describes Halley's contributions including determining Earth's distance to the sun, the motion of stars and predicting the orbit of then-unnamed Halley's Comet using Newton's laws. Tyson contrasts these scientific approaches to understanding the galaxy compared to what earlier civilizations had done, and considers this advancement as mankind's first steps into exploring the universe. The episode ends with an animation of the Milky Way and Andromeda galaxies' merging based on the principles of Newton's laws.

Beginning with the origins of the universe in the Big Bang, Sagan describes the formation of different types of galaxies and anomalies such as galactic collisions and quasars. The episodes moves further into ideas about the structure of the Universe, such as different dimensions (in the imaginary Flatland and four-dimensional hypercubes), an infinite vs. a finite universe, and the idea of an oscillating Universe (similar to that in Hindu cosmology). The search into other ideas such as dark matter and the multiverse is shown, using tools such as the Very Large Array in New Mexico. Cosmos Update shows new information about the odd, irregular surfaces of galaxies and the Milky Way perhaps being a barred spiral galaxy

This episode covers the nature of how life may have developed on Earth and the possibility of life on other planets. Tyson begins by explaining how the human development of writing systems enabled the transfer of information through generations, describing how Princess Enheduanna ca. 2280 BCE would be one of the first to sign her name to her works, and how Gilgamesh collected stories, including that of Utnapishtim documenting a great flood comparable to the story of Noah's Ark. Tyson explains how DNA similarly records information to propagate life, and postulates theories of how DNA originated on Earth, including evolution from a shallow tide pool, or from the ejecta of meteor collisions from other planets. In the latter case, Tyson explains how comparing the composition of the Nakhla meteorite in 1911 to results collected by the Viking program demonstrated that material from Mars could transit to Earth, and the ability of some microbes to survive the harsh conditions of space. With the motions of solar systems through the galaxy over billions of years, life could conceivably propagate from planet to planet in the same manner. Tyson then moves on to consider if life on other planets could exist. He explains how Project Diana performed in the 1960s showed that radio waves are able to travel in space, and that all of humanity's broadcast signals continue to radiate into space from our planet. Tyson notes that projects have since looked for similar signals potentially emanating from other solar systems. Tyson then explains that the development and lifespan of extraterrestrial civilizations must be considered for such detection to be realized. He notes that civilizations can be wiped out by cosmic events like supernovae, natural disasters such as the Toba disaster, or even self-destruct through war or other means, making probability estimates difficult. Tyson describes how elliptical galaxies, in which some of the oldest red dwarf stars exist, would offer the best chance of finding established civilizations. Tyson concludes that human intelligence properly applied should allow our species to avoid such disasters and enable us to migrate beyond the Earth before the Sun's eventual transformation into a red giant.

Professor Brian Cox takes on the story of the force that sculpts the entire universe - gravity. Gravity seems so familiar, and yet it is one of the strangest and most surprising forces in the universe. Starting with a zero gravity flight, Brian experiences the feeling of total weightlessness, and considers how much of an effect gravity has had on the world around us. But gravity also acts over much greater distances. It is the great orchestrator of the cosmos. It dictates our orbit around the sun, our relationship with the other planets in our solar system, and even the way in which our solar system orbits our galaxy. Yet the paradox of gravity is that it is actually a relatively weak force. Brian takes a face distorting trip in a centrifuge to explain how it is that gravity achieves its great power, before looking at the role it plays in one of the most extraordinary phenomena in the universe - a neutron star. Although it is just a few kilometres across, it is so dense that its gravity is 100, 000 million times as strong as on Earth. Over the centuries our quest to understand gravity has allowed us to understand some of the true wonders of the universe, and Brian reveals that it is scientists' continuing search for answers that inspires his own sense of wonder.

Stephen Hawking, the world's most famous living scientist explores the greatest mysteries of the cosmos. In three landmark instalments he reveals the wonders of the universe as never seen before. Definitive, provocative, surprising, and beautiful, Into the Universe with Stephen Hawking is a fascinating look through the mind's eye of one of the finest brains on the planet. In 'Aliens' Hawking considers one of the most important mysteries facing humankind - the possibility of alien, intelligent life. He leads us on a journey rendered in eye-popping detail, from the moons of Jupiter to a galaxy maybe not so far, far away. We will meet possible aliens and wonder at their form, we will delve into the very principles of what it is to call something alive, and we will calculate the likelihood of 'contact' being made.

What if we could explore the vastness of Space? Science fiction has always fed upon our need to explore – to wonder what is out there. Space journeys from Jules Verne’s earliest ideas about attempts to leave our planet, to the Star Wars far away galaxy through to Nichelle Nichols revealing how her groundbreaking role as Lt. Uhura in Star Trek led to her participation in the recruitment of NASA’s astronauts. It explores the deep sea inspiration for Avatar, finds out why Ursula K Le Guin wrote The Left Hand of Darkness and discovers how Stanley Kubrick was able to make 2001: A Space Odyssey seem so believable. In addition, the program looks at the way Dune and The Mars Trilogy embraced the challenge of world building and discusses the appeal of the beaten up ‘dirty space’ of Dark Star and Firefly. From the horrifying scenes of Alien, to the epic spectacle of Star Wars, this is a journey to the stars and the alien encounters that await us there.